Made his acting debut in Canada, in 1908, and subsequently appeared in American vaudeville, in stock, and on the London and Broadway stage. In films from the early 30s, he appeared in numerous productions, typically portraying master criminals (Professor Moriarty, etc.), mad scientists, and an assortment of other archvillains.

Filmography of George Zucco

• 1931 The Dreyfus Case/Dreyfus (UK)
• 1933 The Good Companions (UK)
• 1934 Autumn Crocus (UK)
• 1936 After the Thin Man
• 1936 The Man Who Could Work Miracles (UK)
• 1937 Conquest/Maria Walewska
• 1937 The Firefly
• 1937 London By Night
• 1937 Parnell
• 1937 Rosalie
• 1937 Saratoga
• 1937 Souls at Sea
• 1938 Arsene Lupin Returns
• 1938 Marie Antoinette
• 1938 Suez
• 1939 The Adventures of Sherlock Holmes as Moriarty
• 1939 Captain Fury
• 1939 The Cat and the Canary
• 1939 The Hunchback of Notre Dame
• 1940 Arise, My Love
• 1940 The Mummy's Hand
• 1940 New Moon
• 1941 Ellery Queen and the Murder Ring
• 1941 The Monster and the Girl
• 1941 A Woman's Face
• 1942 The Black Swan
• 1942 The Mummy's Tomb
• 1942 My Favorite Blonde
• 1943 The Black Raven
• 1943 Dead Men Walk
• 1943 The Mad Ghoul
• 1944 House of Frankenstein
• 1944 The Mummy's Ghost
• 1944 The Seventh Cross
• 1944 Voodoo Man
• 1945 Confidential Agent
• 1945 Fog Island
• 1945 Having Wonderful Crime
• 1945 Sudan
• 1947 Captain From Castile
• 1947 Lured
• 1947 Moss Rose
• 1948 Joan of Arc
• 1948 The Pirate
• 1949 Madame Bovary
• 1951 David and Bathsheba
• 1951 The First Legion